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Welcome to the January 2009 issue. This issue addresses the important discussion on cell mechanics. Acute need to study cell mechanics is driven by the fundamental goal of tissue engineering i.e. to make tissue engineered constructs that can mimic the environment for tissue regeneration with a potential to replace the biological functions of damaged organs. There is now worldwide activity in the in vitro regeneration of tissues including nerve, liver, bone, heart valves, blood vessels, and kidney.