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An overview of bio-mechanical models for bones and related topics

Hi everyone!

I'm looking for a good comprehencive overview about bio-mechanics and numerical simulation in

bio-mechanics. I'm mainly interested in the following topics:

-- mathematical models for bone simulation

-- contact problems and corresponding models (e.g., bone-prosthesis models, etc.)

-- corresponding numerics/simulations

and corresponding state-of-the-art.

Thanks in advance! 


MichelleLOyen's picture

North American Workshop on Applications of the Physics of Porous Media

The 7th North American Workshop on Applications of the Physics of Porous Media will be held in Puerto Vallarta, Mexico, November 2-6, 2007. This will be the 7th biennial meeting of researchers around the world who are interested in the phenomena associated with physics of fluid flow and deformation in porous media and its applications to a broad range of basic roblems encountered in geophysics, geomechanics, medical physics, and condensed matter physics.

Full details are available at the website:

Fang Wang's picture


The present paper studies the effect of intracranial temperature (ICT) change on intracranial pressure (ICP). Thermal and mechanical effects were analyzed using a 3D finite element model of the human head.

Fang Wang's picture

Effects of Head Size and Morphology on Dynamic Responses to Impact Loading

Head responses subjected to impact loading are studied using the finite element method. The dynamic responses of the stress, strain, strain energy density and the intracranial pressure govern the intracranial tissues and skull material failures, and therefore, the traumatic injuries.

Fang Wang's picture


Head traumatic injury due to the impact of a flying golf ball is one of the severest injuries sustained on a golf course. This paper presents numerical simulation results based on the finite element (FE) method to investigate head injuries in children due to impacts by flying golf balls.

MichelleLOyen's picture

Fundamentals of Nanoindentation and Nanotribology IV at MRS Fall 2007

First announcement and call for papers.

The symposium "Fundamentals of Nanoindentation and Nanotribology" will run for the fourth time at the Fall, 2007, Materials Research Society Meeting, Boston, MA, USA.   

Zhigang Suo's picture

The comings and goings in a cell

Update 23 March 2007.  This wonderful educational video has now been removed from YouTube because it violates copyright.  What a pity!

Andre of Biocurious has just pointed out this terrific animation of the dynamics inside a cell. It brings many pages of textbook to life. Delightful. I've just followed Teng Li's instruction to embed the YouTube video below.

Analysis of a golf ball hitting the eye

Purpose of the Study
Computer models of the human eye were constructed for the purposes of studying interactions with foreign bodies.

  • Based on in vivo patient data
  • Multi-part model
  • Mixed volumetric and surface meshes
  • Automated generation of contact surfaces

Scan and Segmentation in ScanIP
High resolution in vivo MRI scans of a 29 year old Caucasian female was obtained using both a surface and a head coil on a Philips Gyroscan 1.5 Tesla imager. The following structures were segmented from the 3D data set by a Physician: the globe and optic nerve, the bony orbit, the eyelids and facial soft tissues, the extra-ocular muscles.

Mesh Generation in +ScanFE
A number of finite element models were generated based on the segmented image data. Each structure was meshed with mixed hexahedral and tetrahedral elements. The contact surfaces are particularly robust as the master and slave contact faces are paired - contact structures were exported as volumetric meshes and as surface meshes as required. For this application, the bony orbit was modelled as a rigid structure defined by surface shell elements rather than as a volumetric mesh thereby providing some computational saving.

FE Analysis in LS-DYNA
An analysis of a golf ball hitting the eye was carried out to demonstrate the robustness of the model for simulation purposes, as well as to demonstrate the remarkable sophistication of biological models which can now be generated based on in vivo data. This case study was developed in collaboration with Naomi Green at ARUP, Solihull, UK.

Simpleware signs up reseller in China

Simpleware Ltd., the world leader in image-based meshing software, has signed an agreement with Gaitech International Ltd. to resell the Simpleware suite of software products in China, Hong Kong, Taiwan and Macao.

Simpleware software offers an advanced solution to problems that were previously intractable due to the complexity in geometry reconstruction. Simpleware's technology has opened up numerical analysis (CFD and FEA) to a variety of applications, including biomedical engineering, material characterisation and industrial reverse engineering.

MichelleLOyen's picture

Second International Conference on Mechanics of Biomaterials and Tissues

Abstracts are due April 27, 2007 for the Second International Conference on Mechanics of Biomaterials and Tissues, to take place on the Hawai’ian island of Kaua’i. Full call for papers is at the conference website. The conference is hosted by Elsevier and the launch of a new Elsevier journal on biomechanics will coincide with the timing of the meeting. (The official journal website is here.)

MichelleLOyen's picture

New Biomechanics Journal

A new journal has been started, "Journal of the Mechanical Behavior of Biomedical Materials," to be published by Elsevier from November, 2007. From the Journal's website:

HCHan's picture

Adaptation of arteries to pressure changes

Arteries are living organs that can remodel themself in response to stress changes. Arterial remodeling is a big topic and this paper shows only a tip of the iceberg.

International Journal for Computational Vision and Biomechanics

International Journal for Computation Vision and Biomechanics - Announcement and First Call for papers

ISSN: 0973-6778

Subject: Computational Vision and Biomechanics

Frequency: 2 issues per year

Start date: First trimester of 2007

Dear Colleague,

It is a pleasure to announce the new International Journal for Computation Vision and Biomechanics (IJCV&B) and its first call for papers.

International ECCOMAS Thematic Conference VipIMAGE 2007


17-19th October 2007, FEUP, Porto, Portugal

Dear Colleague,

The International Conference VipIMAGE - I ECCOMAS THEMATIC CONFERENCE ON COMPUTATIONAL VISION AND MEDICAL IMAGE PROCESSING will be held in the Faculty of Engineering of University of Porto, Porto, Portugal, on October 17-19, 2007.

MichelleLOyen's picture

Journal Club Theme of January 2007: Biomechanics and Non-Affine Kinematics

Choose a channel featured in the header of iMechanica: 

Biological materials are frequently constructed of hydrated biopolymer networks. Examples include fibrous collagen in the extracellular matrix and actin within the cell's cytoskeleton. There are differences in the molecular composition of the biopolymer subunits as well as differences in the network density and organization. Images can be seen here and here for dense collagen networks and for portions of actin networks look at images here and here.

MichelleLOyen's picture

New Book "Tissue Mechanics"

A new book, "Tissue Mechanics" by SC Cowin and SB Doty is of potential interest to those from a classical mechanics background considering work in biomechanics. Downloadable versions of the first two chapters are available at the book's website along with a full table of contents and other supplemental information.

Biomaterials faculty position at Lehigh University

I am chairing the search for a new faculty member in the Materials Science and Engineering Department at Lehigh. As you will see in the ad below, the position is in the Biomaterials area. I would like to encourage more applications from candidates with interests in biomechanics (so I will have good opportunities to collaborate), and would like to invite applicants from this forum. If you are not personally in a position to apply, please pass the announcement along to anyone you know who might be suitable.

MichelleLOyen's picture

ASME Summer Bioengineering Conference

Abstract submission is now open for the 2007 ASME Summer Bioengineering Conference, 20-24 June, 2007 in Keystone, Colorado. Full details can be found on the conference website. Please note that there is a vibrant and competitive student paper competition for different

Ashkan Vaziri's picture

Mechanics and deformation of the nucleus in micropipette aspiration experiment

Robust biomechanical models are essential for studying the nuclear mechanics and can help shed light on the underlying mechanisms of stress transition in nuclear elements. Here, we develop a computational model for an isolated nucleus undergoing micropipette aspiration. Our model includes distinct components representing the nucleoplasm and the nuclear envelope. The nuclear envelope itself comprises three layers: inner and outer nuclear membranes and one thicker layer representing the nuclear lamina.

A structure-based sliding-rebinding mechanism for catch bonds

This is a paper by Jizhong Lou and myself, which is in press in Biophysical Journal.

Abstract.  Catch bonds, whose lifetimes are prolonged by force, have been observed in selectin-ligand interactions and other systems. Several biophysical models have been proposed to explain this counter-intuitive phenomenon, but none was based on the structure of the interacting molecules and the noncovalent interactions at the binding interface. Here we used molecular dynamics simulations to study changes in structure and atomic-level interactions during forced unbinding of P-selectin from P-selectin glycoprotein ligand-1. A mechanistic model for catch bonds was developed based on these observations. In the model, "catch" results from forced opening of an interdomain hinge that tilts the binding interface to allow two sides of the contact to slide against each other. Sliding promotes formation of new interactions and even rebinding to the original state, thereby slowing dissociation and prolonging bond lifetimes. Properties of this sliding-rebinding mechanism were explored using a pseudo-atom representation and Monte Carlo simulations. The model has been supported by its ability to fit experimental data and can be related to previously proposed two-pathway models.

How can we obtain more information from protein structure?

We know - or believe - protein function is determined by structure. Crystallographic and NMR studies can provide protein structures with atomic-level details at equilibrium. MD simulations can follow protein conformational changes in time with fs temporal resolution in the absence or presence of a bias mechanism, e.g., applied force, used to induce such changes.

Alexander A. Spector's picture

Mechanics vs. Biochemistry in Adhesions-Cytoskeleton-Nucleus Signal Transduction in Cells

The essence of mechanobiology is, probably, the interrelation between mechanical and biochemical factors.  An exciting example of such phenomenon is signaling associated with the interaction between the cell and extracellular matrix (EM).  While some purely biochemical pathways initiated in the area of contact of the cell and EM are known, there are interesting ideas how the mechanical forces, stresses and strains can be involved too. This view goes back to works of Donald Ingber's group in the 90s that showed how perturbations of the adhesion area as a whole and of an individual integrin result in deformation of the cell nucleus. Interestingly, a distinguished oncologist at Johns Hopkins, Donald Coffey, published similar experimental results about the same time, and he also demonstrated that the observed cytoskeleton/nucleus interaction is different in tumor cells. There are several separate pieces of the puzzle that have been resolved: mechanical forces are generated at focal adhesions, the cytoskeleton is involved, nucleus deforms, gene expression changes as a result of perturbation of the adhesions, however, the whole picture of the interrelated mechanical and biochemical factors has yet to be understood. We recently published some results on this topic in the Journal of Biomechanical Engineering (Jean et al., 2004 and 2005). I was glad to find an interest in the same problem from some participants of this website (e.g., N. Wang, Z. Suo,   Long-distance propagation of forces in a cell, 2005 and P.R. LeDuc and R.M. Bellin, Nanoscale Intracellular Organization and Functional Architecture Mediating Cellular Behavior, 2006). This aspect of mechanotransduction is important for many areas beyond mechanics such as cancer, wound healing, cell adhesion and motility, effect of surface micro- and nanopatterning, etc.

Ning Wang's picture

Long-distance propagation of forces in a cell

What might be the differences, if there is any, between mechanical signaling and chemical signaling in a living cell?


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