The paramount role of mechanics in life has recently been the center of attention of many researchers. This special issue will be focusing on the role of mechanics in the life of cells and tissues and their interactions with biomaterials. Original research and review papers are solicited for review and publication in the journal Mechanical Sciences . Mechanical Sciences is an academic open-access journal sponsored by the Library of Delft University of Technology and The Netherlands Organization for Scientific Research (NWO). Thanks to the generous financial support of The Netherlands Organization for Scientific Research, all manuscripts will be processed and published free of any charge.