The aim of this project is to combine computing and experimental methods to improve our
knowledge in the bone cells interactions with their environment in the context of bone
remodelling. Indeed, bone cells are able to sense their environment and then to adapt
themselves. In this project three main avenues of researches are proposed: i/ to study the mass
transport phenomena in the vicinity of bone cells, that is to say within the pericellular matrix; ii/
to quantify the hydro-mechanical coupling by estimating the 3D-shear effects; iii/using perfusing
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