iMechanica - bio-MEMS
https://imechanica.org/taxonomy/term/9461
enPostdoctoral position in mechanobiology, Buffalo, New York
https://imechanica.org/node/18068
<div class="field field-name-taxonomy-vocabulary-6 field-type-taxonomy-term-reference field-label-hidden"><div class="field-items"><div class="field-item even"><a href="/taxonomy/term/73">job</a></div></div></div><div class="field field-name-taxonomy-vocabulary-8 field-type-taxonomy-term-reference field-label-hidden"><div class="field-items"><div class="field-item even"><a href="/taxonomy/term/871">postdoc</a></div><div class="field-item odd"><a href="/taxonomy/term/2680">mechanobiology</a></div><div class="field-item even"><a href="/taxonomy/term/9461">bio-MEMS</a></div><div class="field-item odd"><a href="/taxonomy/term/1602">cell mechanics</a></div></div></div><div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even"><p>One postdoctoral position will be available in Fall, 2015 in the Department of Biomedical Engineering at the State University of New York at Buffalo (SUNY). The research area will focus on using bio-MEMS techniques to create novel cell culture platforms for cell mechanics and mechanobiological studies. Projects may involve studies of the fibrosis diseases, cancer invasion and stem cell differentiation. Some research topics can be found on our website at <a href="http://www.acsu.buffalo.edu/~rgzhao/index.html">http://www.acsu.buffalo.edu/~rgzhao/index.html</a></p>
<p>Successful candidates shall have photolithography-based microfabrication experience, cell culture experience, experience in mechanobiology and experience in experimental and analytical solid mechanics. Highly motivated and self-driven candidates with experience in at least two of the above areas are encouraged to apply. Salary for suitably qualified applicants is competitive and commensurate with experience. University at Buffalo School of Engineering is one of the top 60 engineering schools in the United States. The Biomedical Engineering department is a joint department between the School of Engineering and the School of Medicine and Biological Science.</p>
<p>If interested, please send your CV and a brief cover letter to Dr. Ruogang Zhao at <a href="mailto:rgzhao@buffalo.edu">rgzhao@buffalo.edu</a>. Thank you.</p>
</div></div></div>Tue, 17 Mar 2015 19:36:49 +0000ruogang zhao18068 at https://imechanica.orghttps://imechanica.org/node/18068#commentshttps://imechanica.org/crss/node/18068Force-driven evolution of mesoscale structure in engineered 3D microtissues and the modulation of tissue stiffening
https://imechanica.org/node/16496
<div class="field field-name-taxonomy-vocabulary-6 field-type-taxonomy-term-reference field-label-hidden"><div class="field-items"><div class="field-item even"><a href="/taxonomy/term/76">research</a></div></div></div><div class="field field-name-taxonomy-vocabulary-8 field-type-taxonomy-term-reference field-label-hidden"><div class="field-items"><div class="field-item even"><a href="/taxonomy/term/19">biomechanics</a></div><div class="field-item odd"><a href="/taxonomy/term/321">biological materials</a></div><div class="field-item even"><a href="/taxonomy/term/6952">tissue mechanics</a></div><div class="field-item odd"><a href="/taxonomy/term/9461">bio-MEMS</a></div><div class="field-item even"><a href="/taxonomy/term/9737">Engineered tissue</a></div></div></div><div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even"><p>
<strong>Force-driven evolution of mesoscale structure in engineered 3D microtissues and the modulation of tissue stiffening</strong>
</p>
<p>
Ruogang Zhao, Christopher S. Chen, Daniel H. Reich, <em>Biomaterials</em>, Vol. 35, Issue 19, June 2014, Pg 5056–5064
</p>
<p>
<a href="http://www.sciencedirect.com/science/article/pii/S0142961214001604">http://www.sciencedirect.com/science/article/pii/S0142961214001604</a>
</p>
<p>
Abstract:
</p>
<p>
The complex structures of tissues determine their mechanical strength.<br />
In engineered tissues formed through self-assembly in a mold,<br />
artificially imposed boundary constraints have been found to induce<br />
anisotropic clustering of the cells and the extracellular matrix in<br />
local regions. To understand how such tissue remodeling at the<br />
intermediate length-scale (mesoscale) affects tissue stiffening, we used<br />
a novel microtissue mechanical testing system to manipulate the<br />
remodeling of the tissue structures and to measure the subsequent<br />
changes in tissue stiffness. Microtissues were formed through cell<br />
driven self-assembly of collagen matrix in arrays of micro-patterned<br />
wells, each containing two flexible micropillars that measured the<br />
microtissues' contractile forces and elastic moduli via magnetic<br />
actuation. We manipulated tissue remodeling by inducing myofibroblast<br />
differentiation with TGF-β1, by varying the micropillar spring constants<br />
or by blocking cell contractility with blebbistatin and collagen<br />
cross-linking with BAPN. We showed that increased anisotropic compaction<br />
of the collagen matrix, caused by increased micropillar spring constant<br />
or elevated cell contraction force, contributed to tissue stiffening.<br />
Conversely, collagen matrix and tissue stiffness were not affected by<br />
inhibition of cell-generated contraction forces. Together, these<br />
measurements showed that mesoscale tissue remodeling is an important<br />
middle step linking tissue compaction forces and tissue stiffening.
</p>
</div></div></div>Mon, 28 Apr 2014 16:12:19 +0000ruogang zhao16496 at https://imechanica.orghttps://imechanica.org/node/16496#commentshttps://imechanica.org/crss/node/16496Force-driven evolution of mesoscale structure in engineered 3D microtissues and the modulation of tissue stiffening
https://imechanica.org/node/16495
<div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even"><p>
Ruogang Zhao, Christopher S. Chen, Daniel H. Reich, <em>Biomaterials</em>, Vol. 35, Issue 19, June 2014, Pg 5056–5064
</p>
<p>
Abstract:
</p>
<p>
The complex structures of tissues determine their mechanical strength.<br />
In engineered tissues formed through self-assembly in a mold,<br />
artificially imposed boundary constraints have been found to induce<br />
anisotropic clustering of the cells and the extracellular matrix in<br />
local regions. To understand how such tissue remodeling at the<br />
intermediate length-scale (mesoscale) affects tissue stiffening, we used<br />
a novel microtissue mechanical testing system to manipulate the<br />
remodeling of the tissue structures and to measure the subsequent<br />
changes in tissue stiffness. Microtissues were formed through cell<br />
driven self-assembly of collagen matrix in arrays of micro-patterned<br />
wells, each containing two flexible micropillars that measured the<br />
microtissues' contractile forces and elastic moduli via magnetic<br />
actuation. We manipulated tissue remodeling by inducing myofibroblast<br />
differentiation with TGF-β1, by varying the micropillar spring constants<br />
or by blocking cell contractility with blebbistatin and collagen<br />
cross-linking with BAPN. We showed that increased anisotropic compaction<br />
of the collagen matrix, caused by increased micropillar spring constant<br />
or elevated cell contraction force, contributed to tissue stiffening.<br />
Conversely, collagen matrix and tissue stiffness were not affected by<br />
inhibition of cell-generated contraction forces. Together, these<br />
measurements showed that mesoscale tissue remodeling is an important<br />
middle step linking tissue compaction forces and tissue stiffening.
</p>
<p>
</p>
</div></div></div><div class="field field-name-taxonomyextra field-type-taxonomy-term-reference field-label-above"><div class="field-label">Taxonomy upgrade extras: </div><div class="field-items"><div class="field-item even"><a href="/taxonomy/term/76">research</a></div><div class="field-item odd"><a href="/taxonomy/term/19">biomechanics</a></div><div class="field-item even"><a href="/taxonomy/term/990">biological tissues</a></div><div class="field-item odd"><a href="/taxonomy/term/6952">tissue mechanics</a></div><div class="field-item even"><a href="/taxonomy/term/8423">engineered microtissue</a></div><div class="field-item odd"><a href="/taxonomy/term/9461">bio-MEMS</a></div></div></div>Mon, 28 Apr 2014 16:07:06 +0000ruogang zhao16495 at https://imechanica.orghttps://imechanica.org/node/16495#commentshttps://imechanica.org/crss/node/16495Error | iMechanica