iMechanica - 3D assembly
https://imechanica.org/taxonomy/term/11971
enPNAS: Compliant 3D frameworks instrumented with strain sensors for characterization of millimeter-scale engineered muscle tissues
https://imechanica.org/node/25167
<div class="field field-name-taxonomy-vocabulary-6 field-type-taxonomy-term-reference field-label-hidden"><div class="field-items"><div class="field-item even"><a href="/taxonomy/term/76">research</a></div></div></div><div class="field field-name-taxonomy-vocabulary-8 field-type-taxonomy-term-reference field-label-hidden"><div class="field-items"><div class="field-item even"><a href="/taxonomy/term/11971">3D assembly</a></div><div class="field-item odd"><a href="/taxonomy/term/9737">Engineered tissue</a></div><div class="field-item even"><a href="/taxonomy/term/10986">bioelectronics</a></div></div></div><div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even"><p>In this work published in PNAS (<a href="https://www.pnas.org/content/118/19/e2100077118">https://www.pnas.org/content/118/19/e2100077118</a>), we <span>present compliant 3D frameworks that </span><span>incorporate microscale strain sensors for high-sensitivity measurements </span><span>of contractile forces of engineered optogenetic muscle tissue </span><span>rings, supported by quantitative simulations.</span></p>
<p><span>Abstract: </span></p>
<p><span>Tissue-on-chip systems represent promising platforms for monitoring </span><span>and controlling tissue functions in vitro for various purposes in biomedical </span><span>research. The two-dimensional (2D) layouts of these constructs </span><span>constrain the types of interactions that can be studied and </span><span>limit their relevance to three-dimensional (3D) tissues. The development </span><span>of 3D electronic scaffolds and microphysiological devices with </span><span>geometries and functions tailored to realistic 3D tissues has the potential </span><span>to create important possibilities in advanced sensing and control. </span><span>This study presents classes of compliant 3D frameworks that </span><span>incorporate microscale strain sensors for high-sensitivity measurements </span><span>of contractile forces of engineered optogenetic muscle tissue </span><span>rings, supported by quantitative simulations. Compared with traditional </span><span>approaches based on optical microscopy, these 3D mechanical </span><span>frameworks and sensing systems can measure not only motions but </span><span>also contractile forces with high accuracy and high temporal resolution. </span><span>Results of active tension force measurements of engineered </span><span>muscle rings under different stimulation conditions in long-term monitoring </span><span>settings for over 5 wk and in response to various chemical and </span><span>drug doses demonstrate the utility of such platforms in sensing and </span><span>modulation of muscle and other tissues. Possibilities for applications </span><span>range from drug screening and disease modeling to biohybrid robotic </span>engineering.</p>
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<tr class="odd"><td><span class="file"><img class="file-icon" alt="PDF icon" title="application/pdf" src="/modules/file/icons/application-pdf.png" /> <a href="https://imechanica.org/files/e2100077118.full_.pdf" type="application/pdf; length=2053102">e2100077118.full_.pdf</a></span></td><td>1.96 MB</td> </tr>
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</div></div></div>Mon, 10 May 2021 15:50:16 +0000Hangbo Zhao25167 at https://imechanica.orghttps://imechanica.org/node/25167#commentshttps://imechanica.org/crss/node/25167Morphable 3D mesostructures and microelectronic devices by multistable buckling mechanics
https://imechanica.org/node/22154
<div class="field field-name-taxonomy-vocabulary-6 field-type-taxonomy-term-reference field-label-hidden"><div class="field-items"><div class="field-item even"><a href="/taxonomy/term/76">research</a></div></div></div><div class="field field-name-taxonomy-vocabulary-8 field-type-taxonomy-term-reference field-label-hidden"><div class="field-items"><div class="field-item even"><a href="/taxonomy/term/11971">3D assembly</a></div><div class="field-item odd"><a href="/taxonomy/term/218">buckling</a></div><div class="field-item even"><a href="/taxonomy/term/995">instability</a></div><div class="field-item odd"><a href="/taxonomy/term/11972">3D microelectronic devices</a></div><div class="field-item even"><a href="/taxonomy/term/9158">Advanced Manufacturing</a></div><div class="field-item odd"><a href="/taxonomy/term/5107">Morphing Structures</a></div></div></div><div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even"><p>Reconfigurable electronic devices that can be shaped in two or more stable geometries modifying their functionalities have been realized, as highlighted by the <a href="https://www.nature.com/nmat/volumes/17/issues/3" target="_blank">Cover of March 2018 Issue of Nature Materials</a>.</p>
<p><img src="https://media.springernature.com/w300/springer-static/cover-hires/journal/41563/17/3" alt="Cover image for the March 2018 Issue of Nature Materials" width="159" height="211" /></p>
<p>3D structures capable of reversible transformations in their geometrical layouts have important applications across a broad range of areas. Most morphable 3D systems rely on concepts inspired by origami/kirigami or techniques of 3D printing with responsive materials. The development of schemes that can simultaneously apply across a wide range of size scales and with classes of advanced materials found in state-of-the-art microsystem technologies remains challenging. Here, we introduce a set of concepts for morphable 3D mesostructures in diverse materials and fully formed planar devices spanning length scales from micrometres to millimetres. The approaches rely on elastomer platforms deformed in different time sequences to elastically alter the 3D geometries of supported mesostructures via nonlinear mechanical buckling. Over 20 examples have been experimentally and theoretically investigated, including mesostructures that can be reshaped between different geometries as well as those that can morph into three or more distinct states. An adaptive radiofrequency circuit and a concealable electromagnetic device provide examples of functionally reconfigurable microelectronic devices.</p>
<p>Read the article: <a class="links" href="https://www.nature.com/articles/s41563-017-0011-3" target="_blank">Nature Materials 17, 268-276 (2018) (Cover Feature Article)</a></p>
</div></div></div>Thu, 22 Feb 2018 02:25:17 +0000Yihui Zhang22154 at https://imechanica.orghttps://imechanica.org/node/22154#commentshttps://imechanica.org/crss/node/22154Error | iMechanica