Mechanotransduction of liver sinusoidal endothelial cells under varied mechanical stimuli

Journal Tittle: Acta Mechanica Sinica

Article Tittle: Mechanotransduction of liver sinusoidal endothelial cells under varied mechanical stimuli

Author: Xinyu Shu, Ning Li, Yi Wu, Wang Li, Xiaoyu Zhang, Peiwen Li,Dongyuan Lü, Shouqin Lü, Mian Long

Novelty/impact/significance

Provide valuable guidance to understand the responses in LSECs under mechanical stimuli, including related mechanotransductive pathways and quantitative mechanical parameters.

Scientific question

Introduce a comprehensive summary of mechanical responses in LSECs.

Key of how

Mainly based on literature summary and analysis.

Major points

Typical shear stress, mechanical stretch and substrate stiffness exerted on LSECs can initiate a series of biomechanical signaling where LSECs serve as a mechanical sensor and regulator.

Funding of the work

1.       National Natural Science Foundation of China (Grants 91642203, 31627804, and 31870930)

2.       The Scientific Instrument Developing Project, Strategic Priority Research Program and Frontier Science Key Project of Chinese Academy of Sciences (Grants GJJSTU20190005, QYZDJ-SSW-JSC018 and XDB22040101)

Please go to the website to read this article: http://ams.cstam.org.cn/EN/abstract/abstract157369.shtml