Interactions between bone cells and their vicinity

The aim of this project is to combine computing and experimental methods to improve our

knowledge in the bone cells interactions with their environment in the context of bone

remodelling. Indeed, bone cells are able to sense their environment and then to adapt

themselves. In this project three main avenues of researches are proposed: i/ to study the mass

transport phenomena in the vicinity of bone cells, that is to say within the pericellular matrix; ii/

to quantify the hydro-mechanical coupling by estimating the 3D-shear effects; iii/using perfusing

chamber to evaluate in vitro the consequences of the fluid flow on the cellular response.

This multidisciplinary project requires combining abilities in mechanical and numerical

simulations on the one hand and cellular biology on the other hand. It involves two laboratories

of the University Paris-Est Créteil (UPEC): the Laboratory Modélisation et Simulation Multi

Echelle (MSME, UMR 8208 CNRS) and the Laboratory Croissance, Réparation et Régénération

Tissulaires (CRRET, EAC 7149 CNRS).

The post-doc candidate should have a PhD and would ideally present some skills in

Biomechanics or Mechanobiology. He should be able to participate and understand the issues

in modelling living materials and should also be a proposal task in the experimental validation

process.

For more information about the laboratory, please visit http://msme.univ-mlv.fr/equipebiomecanique/

Application procedure: The application shall be written in English or French.

Please send our cover letter and CV (including publication list, prior research experience and contact

information of two references) as a single pdf file to: salah.naili [at] univ-paris-est.fr and

thibault.lemaire [at] univ-paris-est.fr. Fixed deadline: 5 April 2013.

Contact: Salah Naili (salah.naili [at] univ-paris-est.fr) and Thibault Lemaire

(thibault.lemaire [at] univ-paris-est.fr)

Salary, duration and localisation: Net salary: about 2100€/month (gross salary:

2600€/month). The postdoctoral position is for 12 months and can start in September 2013. The

laboratory is localized at Créteil (Métro Créteil-Université).