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PhD - Dynamics of capsules and polymersomes under flow and in blood

Date of beginning: to negotiate

Location: IRPHE, Aix-Marseilles University, Marseilles, France

Contact: send your CV to boedec@irphe.univ-mrs.fr and leonetti@irphe.univ-mrs.fr

Visit https://www.irphe.fr/-Leonetti-Marc,175- for additional informations.

   The living offers the opportunity to study the behavior of original phenomena in which basic mechanisms remain to be elucidated. Thus, the blood is a suspension of elastic objects, namely red blood cells, whose large deformability in the vessels gives it the rheological
properties of complex fluid (Fahraeus-Lindqvist effect), and inherently multiscale.
   The living is also a source of inspiration for designing new physical systems. Thus, there
is now a wide variety of systems constituted of a closed membrane immersed in a fluid: vesicles, capsules, polymersomes, the colloidosomes ... Each object has its own elastic properties, in order to meet the multiple demands of engineering in the fields of cosmetics, food, pharmacy, biology... But they also provide a way to mimic the rheology of blood by targeting the best physical characteristics of the membrane to form models of living systems.
Our group tackles these questions by way of experimental as well as theoretical-numerical
investigations.
Here, the proposed subject is theoretical and numerical. It aims to better understand the
coupling phenomena between the membrane of a capsule or polymersome and simple flows. A
spherical capsule has the striking ability to buckle and thus to make wrinkles at the membrane
due to the flow stress. The polymersome membrane has a high 2D shear viscosity locating dissipation at membrane and not in the bulk as vesicles. This is peculiarly true when the characteristic size becomes small such as in the case of tubes and pearling instability. We propose to address the problem of complex soft particles under flow.

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