The aim of the research project is to develop a means of identifying alterations in collagen fibre architecture of arteries in vivo using non-invasive imaging techniques that can be linked with disease progression. DT-MRI has been used to characterise fibre patterns in animal tissue and this project will explore the means by which this can be enhanced in human tissue. Potential applications of the NODDI (neurite orientation dispersion and density imaging) protocol in arterial tissue will be explored.
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