A Finite Element Study of Micropipette Aspiration of Single Cells: Effect of Compressibility
Abstract
Abstract
Hi everybody. My name is Alexander Lyapin. I am a second year postgraduate student of Southern Federal University, Russia, Rostov-on-Don, and I am working in the field of poroelasticity. The topic of my future dissertation is "Dynamic problems of poroelastic enviroments". The main problems in my dissertation are fundamental solutions and enviroments with cavities of common arbitary shape. I use different methods such as boundary integral equations method Fourie transformation method and some other.
We develop a method of poroelastic relaxation indentation (PRI) to characterize thin layers of gels. The solution to the time-dependent boundary-value problem is obtained in a remarkably simple form, so that the force-relaxation curve obtained by indenting a gel readily determines all the poroelastic constants of the gel—the shear modulus, Poisson’s ratio, and the effective diffusivity. The method is demonstrated with a layer of polydimethylsiloxane immersed in heptane.
This paper studies the poroelastic behavior of an alginate hydrogel by a combination of theory and experiment. The gel—covalently crosslinked, submerged in water and fully swollen—is suddenly compressed between two parallel plates. The gap between the plates is held constant subsequently, and the force on the plate relaxes while water in the gel migrates. This experiment is analyzed by using the theory of linear poroelasticity.
This paper uses a method based on indentation to characterize a polydimethylsiloxane (PDMS) elastomer submerged in an organic solvent (decane, heptane, pentane, or cyclohexane). An indenter is pressed into a disk of a swollen elastomer to a fixed depth, and the force on the indenter is recorded as a function of time. By examining how the relaxation time scales with the radius of contact, one can differentiate the poroelastic behavior from the viscoelastic behavior. By matching the relaxation curve measured experimentally to that derived from the theory of poroelasticity, o
When an indenter is pressed into a gel to a fixed depth, the solvent in the gel migrates, and the force on the indenter relaxes. Within the theory of poroelasticity, the force relaxation curves for indenters of several types are obtained in a simple form, enabling indentation to be used with ease as a method for determining the elastic constants and permeability of the gel. The method is demonstrated with a conical indenter on an alginate hydrogel.
Does anyone have experience using poroelasticity model? I dont underestand the abaqus model -the logarithmic bulk modulus and.., where are these coming from?Is anyone knows a reference book to link those?
Research activities on soil models, porous media, poroelasticity.