A new perspective on model reduction for nonlinear multi-scale analysis of heterogeneous materials. In this work, we seek meaningful low-dimensional structures hidden in high-dimensional multi-scale data.
Recently, unusually high detachment rates of a myosin from actin were reported with a force spectroscopy technique. Here, we show that these high rates may be due to the coupling between bond breaking and state transition. Based on a kinetic model for single myosin, rates of bond breaking between myosin and actin at different nucleotide states are systematically extracted for the first time. Our results clearly indicate that myosins may adopt much higher transition rates than bond breaking rates at different nucleotide states at relatively low forces.
Two PhD scholarships and one PhD/postdoc scholarship within the field of biomechanical modeling/ engineering and 3D multimodal imaging technology is available at NTNU, Trondheim, Norway
Project description
A Doctorate of Engineering (DE) student positions is available for Summer/Fall 2016 in Mechanical Engineering. The applicants are required to have master degree. The positions are directed by Multiscale Contact Mechanics and Tribology Laboratory and Optoelectronic Laboratory at Lamar University, Beaumont, TX, USA. Interested applicants may find more information at http://engineering.lamar.edu/mechanical/ and are encouraged to apply ASAP.
The presence of nano-sized coherent precipitates is well known to have crucial impact on the mechanical behaviors of a broad class of shape memory alloys. The local stress gradient at the matrix-precipitate interface is predicted as induced by inter-lattice atomic disregistry. Due to the presence of the local disturbance fields, the preference for activating different martensitic variants, given the uni-directionality thereof, is influenced substantially.
7th Summer School on Biomechanics of Soft Tissues: Multiscale Modeling, Simulation and Applications
Graz University of Technology, Austria
July 4 - 8, 2016
coordinated by:
Gerhard A. Holzapfel, Graz University of Technology, Austria
Ray W. Ogden, University of Glasgow, UK
Dear Mechanics Community
We welcome applications for a post-doctoral position in the Multiscale Computational Mechanics Laboratory (MCML) at Vanderbilt University. MCML is a part of the interdisciplinary Multiscale Modeling and Simulation (MuMS) facility.
Fatigue life prediction in the aerospace components relies on fracture mechanics for relatively long cracks (>1mm). Nevertheless, most of the fatigue life is spent while the crack is relatively short (<1mm). However life of short cracks is far from well understood leading engineers to apply over conservative safety factors which involves environmental and economic losses. The material microstructure is responsible for the large life uncertainty in short cracks.
Date: Thursday, March 17, 2016
Time: 10.00 am – 2.00 pm
Venue: Wyndham Houston West - Energy Corridor, 14703 Park Row, Houston, TX 77079
Fee: free-to-attend
