Rac activation by stress does not depend on Src
It is known that platelet derived growth factor (PDGF) induced Rac activation depends on Src activity. However, we find that a local stress of physiologic magnitude via integrins can directly activate Rac GTPase rapidly, independent of the Src activity. Our finding on the stress-induced rapid Rac activation challenges the conventional wisdom on mechanotransduction and suggests that stress-induced signaling via focal adhesions does not follow signal transduction pathways induced by growth factors. To view the whole paper: