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cell mechanics

Teng Li's picture

Mechanics of microtubule buckling in living cells

As the most rigid cytoskeletal filaments, microtubules bear compressive forces in living cells, balancing the tensile forces within the cytoskeleton to maintain the cell shape. It is often observed that, in living cells, microtubules under compression severely buckle into short wavelengths. By contrast, when compressed, isolated microtubules in vitro buckle into single long-wavelength arcs. The critical buckling force of the microtubules in vitro is two orders of magnitude lower than that of the microtubules in living cells.

Tian Zhi Luo's picture

MD simulation of the cell shape change during cytokinesis

The simulation was conducted under constant force condition. Initially, the cell had a spherical shape. After being deformed by the virtual forces that were applied on the molecules on the middle great circle, the cell underwent continuous shape changes. The virtual forces were originated from the myosin motion along the actin filaments in the contractile ring.

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Tian Zhi Luo's picture

coarse grained MD simulation of cell division associated with the z-ring structure

The simulation code is written according the article published by J. Li et al. in Biophysics Journal 2005. The force associated with the z-ring is applied in the middle of a cylindrical cell. Continuum solution of the cell division can be found in the paper published by G. Lan et al. in PNAS 2006.

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Entropic-elasticity-controlled dissociation and energetic-elasticity-controlled rupture induce catch to slip bonds in cell-adhes

In order to achieve a wide variety of biological phenomena, the abilities of cells to contact effectively and interact specifically with neighboring media play a central role. It is known that cells can sense the chemical and mechanical properties of surrounding systems and regulate their adhesion and movement through binding protein molecules within cell membrane. The kinetics of binding molecules interacting with ligands is of great interest in biophysical society. There are lots of discussions and contributions on cell mechanics from our mechanical society, e.g.

Recruiting PhD students for Cell Mechanics Lab at Rensselaer

Full support is available for 2 PhD students in cellular mechanics group in Biomedical Engineering Department at Rensselaer Polytechnic Institute.  

The applicants should have mechanics, materials or soft matter physics background, with some experimental experience at micro-scales.  Experience with any of the following is considered a
plus: computational mechanics, cell/tissue culture, microscopy, image analysis, photonics.


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