ES 240 project: Deformation of the Sarcolemma
The cardiac myocyte is the basic contractile unit of the heart. In addition to potentiating contraction through chemical and electrical means, each myocyte is a complex sensor that monitors the mechanics of the heart. Through largely unknown means, mechanical stimuli are transduced into biochemical information and responses. Such mechanotransduction has been implicated in the etiology of many cardiovascular pathologies [1]. One such mechanical parameter that the myocyte most likely monitors is the hydrostatic pressure in the myocardium.