Long-distance propagation of forces in a cell
What might be the differences, if there is any, between mechanical signaling and chemical signaling in a living cell?
What might be the differences, if there is any, between mechanical signaling and chemical signaling in a living cell?
There has been a lot of attention on the study of mechanics of proteins and/or single molecules. Such study was typically implemented by using classical molecular dynamics (MD) simulation. In spite of ability to describe the dynamics of biological macromolecules (e.g. proteins), MD simulation exhibits the computational restriction in the spatial and temporal scale. In order to overcome such computational limitation, the coarse-grained model has recently been taken into account. In this review, I would take a look at a couple of coarse-grained models of protein molecules.
Questions about meshfree methods are now addressed in the forum, under the Computational Mechanics subheading.
If you click on a question below, you will be redirected to the forum. I will update this post as more questions are added. Other experts are encouraged to augment my response there.
2. Is a mesh required in meshfree methods?
In fact, this is a common misconception with meshfree methods. Shape functions that satisfy Kronecker-Delta take a value of one at the node, and vanish at every other node in the domain. Finite element shape functions, for example, are usually designed with this property. This makes the satisfaction of essential boundary conditions relatively simple: we just set or fix the degree of freedom at the node to what it should be on the boundary. Unfortunately, this is usually not sufficient to impose essential boundary conditions with meshfree methods.
The issue is that meshfree shape functions associated with nodes located on the interior of the domain do not typically vanish on the boundary. So, what happens between nodes is just as important as what happens at the nodes. An excellent paper discussing the various options for imposing essential boundary conditions with meshfree methods is provided by Fernandez-Mendez and Huerta, Computer Methods in Applied Mechanics and Engineering, 193, pp. 1257-1275, 2004. At present, Nitsche's method is accepted as being the most robust for essential boundary conditions with meshfree methods. It should also be noted that with Natural-Neighbor interpolants, this is not an issue and the boundary conditions can be imposed just like they are with finite elements.
We published this paper in APL on a study of the deformation near interfaces. It provides insight in the strain localization at the interface and its influence on the deformation in bulk metals.
Abstract An optical full-field strain mapping technique has been used to provide direct evidence for the existence of a highly localized strain at the interface of stacked Nb/Nb bilayers during the compression tests loaded normal to the interface. No such strain localization is found in the bulk Nb away from the interface. The strain localization at the interfaces is due to a high void fraction resulting from the rough surfaces of Nb in contact, which prevents the extension of deformation bands in bulk Nb crossing the interface, while no distinguished feature from the stress-strain curve is detected.
As you know, the volumetric expansion by 9% during the water-to-ice transition can generate tremendous pressure in a confined space is a common sense. As a result, one may expect freezing water to also fracture rocks.
However, in a recent article in Science, Bernard Hallet explains the power of the 9% water-to-ice expansion in confined spaces is undeniable, but it may rarely be significant for rocks under natural conditions, because it requires a tight orchestration of unusual conditions. Unless the rocks are essentially saturated with water and frozen from all sides, the expansion can simply be accommodated by the flow of water into empty pores, or out of the rock through its unfrozen side.
I think it may be of interest to mechanics. Read more
I hope to hear opinions from people who know about the breaking mechanics of rocks.
This is a paper we recently published in JMPS on a study of the mechanical properties on thin films comparing experimental results with discrete dislocation simulations. It provides insight in the strengthening that occurs in thin metal films when surface or interface effects become important.
The abstract is below; the full paper can be downloaded from here
Abstract - Experimental measurements and computational results for the evolution of plastic deformation in freestanding thin films are compared. In the experiments, the stress–strain response of two sets of Cu films is determined in the plane-strain bulge test. One set of samples consists of electroplated Cu films, while the other set is sputter-deposited. Unpassivated films, films passivated on one side and films passivated on both sides are considered. The calculations are carried out within a two-dimensional plane strain framework with the dislocations modeled as line singularities in an isotropic elastic solid. The film is modeled by a unit cell consisting of eight grains, each of which has three slip systems. The film is initially free of dislocations which then nucleate from a specified distribution of Frank–Read sources. The grain boundaries and any film-passivation layer interfaces are taken to be impenetrable to dislocations. Both the experiments and the computations show: (i) a flow strength for the passivated films that is greater than for the unpassivated films and (ii) hysteresis and a Bauschinger effect that increases with increasing pre-strain for passivated films, while for unpassivated films hysteresis and a Bauschinger effect are small or absent. Furthermore, the experimental measurements and computational results for the 0.2% offset yield strength stress, and the evolution of hysteresis and of the Bauschinger effect are in good quantitative agreement.
It is well-recognized that MEMS switches, compared to their more traditional solid state counterparts, have several important advantages for wireless communications. These include superior linearity, low insertion loss and high isolation. Indeed, many potential applications have been investigated such as Tx/Rx antenna switching, frequency band selection, tunable matching networks for PA and antenna, tunable filters, and antenna reconfiguration.
However, none of these applications have been materialized in high volume products to a large extent because of reliability concerns, particularly those related to the metal contacts. The subject of the metal contact in a switch was studied extensively in the history of developing miniaturized switches, such as the reed switches for telecommunication applications. While such studies are highly relevant, they do not address the issues encountered in the sub 100mN, low contact force regime in which most MEMS switches operate. At such low forces, the contact resistance is extremely sensitive to even a trace amount of contamination on the contact surfaces. Significant work was done to develop wafer cleaning processes and storage techniques for maintaining the cleanliness. To preserve contact cleanliness over the switch service lifetime, several hermetic packaging technologies were developed and their effectiveness in protecting the contacts from contamination was examined.
I am very happy to be part of iMechanica, and what best way to start than post some stuff that I have been doing recently. I received my PhD for a thesis I submitted to the Department of Materials Engineering (formerly Department of Metallurgy), Indian Institute of Science, Bangalore 560012 INDIA titled Elastic Inhomgeneity Effects on microstructures: a phase field study.
A mismatch in elastic moduli is the primary driving force for certain microstructural changes; for example, such a mismatch can result in rafting, phase inversion, and thin film instability.
My thesis is based on a phase field model, which is developed for the study of microstructural evolution in elastically inhomogeneous systems which evolve under prescribed traction boundary conditions; however, we show that it is also capable of simulating systems which are evolving under prescribed displacements.
The (iterative) Fourier based methodology that we adopt for the solution of the equation of mechanical equilibrium is characterised by comparing our numerical elastic solutions with corresponding analytical sharp interface results; in addition to being accurate, this solution methodology is also very efficient. We integrate this solution methodology into our phase field model, to study microstructural evolution in systems with dilatational misfit.
In a recent article in Physical Review Letters, Alain Goriely and Sébastien Neukirch offer a mechanical model of how the free tip of a twining plant can hold onto a smooth support, allowing the plant to grow upward. The model also explains why these vines cannot grow on supports of too large a diameter. Read more.
The mechanics involves large deflection and bifurcation of a rod. I hope to hear opinions from people who know about the mechanics of plants.