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Intracellular CalciumWaves in Bone Cell Networks Under Single Cell Nanoindentation

In this study, bone cells were successfully cultured into a micropatterned network with dimensions close to that of in vivo osteocyte networks using microcontact printing and self-assembled monolyers (SAMs). The optimal geometric parameters for the formation of these networks were determined in terms of circle diameters and line widths. Bone cells patterned in these networks were also able to form gap junctions with each other, shown by immunofluorescent staining for the gap junction protein connexin 43, as well as the transfer of gap-junction permeable calcein-AM dye.

CFRAC 2007 International Conference on Computational Fracture and Failure of Materials and Structures

If you are interested by the computational aspects of fracture and failure of materials and structures,there is a dedicated conference for you : CFRAC 2007, which will be held in Nantes, France, 11-13 June 2007. It is an thematic conference of the European Community in Computational Methods in Applied Sciences (ECCOMAS). The for abstract is now closed. This conference wil involve a certian number

No need to worry about gravity at the atomic-/nano-scale

When a metal is grown onto a substrate of itself (homoepitaxy), the growth front is typically smooth, or at most is roughened by the formation of shallow hills (called surface mounds). The underlying reason for the roughening has been recognized to be of kinetic nature: Atoms landed on an upper terrace do not have enough time to overcome the "road blocks" provided by the steps and fill all the valleys (known as the Villian instability).

Molecular and Cellular Biomechanics Journal

A new journal dedicated to the field of Molecular and Cellular Biomechanics has been formed for about a year. Many members in this community (such as Ning Wang, Cheng Zhu, Phil LeDuc) are on the board of editors. You may want to check it out....

Zhigang Suo's picture

Some numbers of iMechanica

  • The number of registered users is 6037
  • The number of posts is 2896 (You can see the current number by clicking the newest post).
  • The number of comments is 6943 (You can see the current number by clicking the newest comment.)

Last updated on 19 March 2008

Related post: Some dates of iMechanica

EFG Matlab Routines

These used to be hosted at Northwestern, but the files were taken down some time ago. The original 1d and 2d Matlab routines for the element-free Galerkin method are now located at

These routines are described in detail in the paper

J. Dolbow and T. Belytschko (1998), "An Introduction to Programming the Meshless Element Free Galerkin Method," Archives of Computational Methods in Engineering, vol. 5, no. 3, pp. 207--242.

MichelleLOyen's picture

ASME Summer Bioengineering Conference

Abstract submission is now open for the 2007 ASME Summer Bioengineering Conference, 20-24 June, 2007 in Keystone, Colorado. Full details can be found on the conference website. Please note that there is a vibrant and competitive student paper competition for different

Mass sensing by using a resonating microcantilever

We recently reported the mass sensing by using resonating microcantilevers. The characterization of mass-sensing and its related sensitivity was suggested on the basis of elasticity theory.

Model Reduction of Large Proteins for Normal Mode Studies

Recently, I reported the model reduction method for large proteins for understanding large protein dynamics based on low-frequency normal modes. This work was pubslihed at Journal of Computational Chemistry (click here).

Coarse-Graining of protein structures for the normal mode studies


Researcher Spotlight: Professor Lambert Ben Freund (LBF)

L. Ben FreundLambert Ben Freund (LBF) was born on November 23, 1942, in Johnsburg, Illinois, a tiny rural community of a few hundred people in the northeast corner of the state. This part of the Midwest was opened to European settlement by the Black Hawk War of the 1830s. A small delegation of his ancestors arrived in the area in 1841.

Quantum Stability of Metallic Thin Films and Nanostructures

When a metal system shrinks its dimension(s), the conduction electrons inside the metal feel the squeezing, and are forced into (discrete) quantum states. Such confined motion of the conduction electrons may influence the global or local stability of the low dimensional systems, and in the case of a thin film on a foreign substrate this "quantum energy" of electronic origin can easily overwhelm the strain effects in definging the film stability, thereby severely influencing the preferred growth mode (see, e.g., Suo and Zhang, Phys. Rev. B 58, 5116 (1998)).

Juil Yoon's picture

Spacing effect on dislocation injection from sharp features in strained silicon structures

In practice, the SiN stripes or pads are periodically patterned on silicon, so the spacing effect on dislocation injection from sharp features deserves attention. As in Figure 1, the SiN stripes with residue stress, of width L and thickness h, are periodically patterned with spacing S. In the numerical calculation, we take shear modulus and Poisson’s ratio of Si3N4 to be 54.3 GPa and 0.27, and those of silicon 68.1GPa and 0.22, the same as in Ref.[1].

Symposium on Characterization and Modeling of Time-Dependent Materials and Processes at the 2007 ASME M&M Conference

The Symposium on Characterization and Modeling of Time-Dependent Materials and Processes at the 2007 ASME Mechanics and Materials conference will be held June 3-7, 2007, at the University of Texas at Austin. Additional information about the conference can be found at the conference website.

Papers dealing with modeling and experimental aspects of the subject area, involving all materials, are sought. The mechanical response should be non-negligable in cases involving non-mechanical fields. Possible topics include, but are not limited to: characterization and modeling of behavior at multiple scales; viscoelasticity, viscoplasticity; transport, chemically and electronically active processes; multiphase and biomaterial systems; thermodynamics; shape memory; mechanics of testing; micro/nanoindentation on time-dependent materials; dynamic behavior of polymers and composites; large deformations; residual stresses; time-dependent damage and failure; polycrystalline and single crystal behaviors; multifunctional materials; mechanics of processing.

Leon Mishnaevsky's picture

Postdoctoral Position in Micromechanics and Fatigue of Natural Composites, at Risø National Laboratory, Denmark

Applications are invited from suitably qualified candidates for a Postdoc/Research Scientist position in the framework of a Danish/Nepalese collaborative research project, in the Materials Research Department of Risø National Laboratory, Denmark 

Job description: As a postdoc/scientist, you will carry out numerical micromechanical modelling of fatigue processes in wood. The theme of the project is the computational analysis of the effect of microstructures of natural materials (wood), coatings and other microscale parameters on their fatigue resistance and lifetime under cyclic loading. The experiments and verification of results will be carried out in collaboration with project partners in Kathmandu, Nepal. The deliverables of the project should include the development of recommendations for the improvement of the reliability of wind turbine blades, produced from coated wood in Nepal, as well as extracting “lessons from nature” to be used in the improvement of polymer matrix fiber reinforced composites for wind energy applications.  

Ashkan Vaziri's picture

Mechanics and deformation of the nucleus in micropipette aspiration experiment

Robust biomechanical models are essential for studying the nuclear mechanics and can help shed light on the underlying mechanisms of stress transition in nuclear elements. Here, we develop a computational model for an isolated nucleus undergoing micropipette aspiration. Our model includes distinct components representing the nucleoplasm and the nuclear envelope. The nuclear envelope itself comprises three layers: inner and outer nuclear membranes and one thicker layer representing the nuclear lamina.

Xiaoyan Li's picture

Atomistic simulations for the evolution of a U-shaped dislocation in fcc Al

We show, through MD simulations, a new evolution pattern of the U-shaped dislocation in fcc Al that would enrich the FR mechanism. Direct atomistic investigation indicates that a U-shaped dislocation may behave in different manners when it emits the first dislocation loop by bowing out of an extended dislocation. One manner is that the glissile dislocation segment always bows in the original glide plane, as the conventional FR mechanism. Another is that non-coplanar composite dislocations appear owing to conservative motion of polar dislocation segments, and then bow out along each slip plane, creating a closed helical loop. The motion of these segments involves a cross-slip mechanism by which a dislocation with screw component moves from one slip plane into another. Ultimately, such non-coplanar evolution results in the formation of a FR source.


I am writing to you to bring to your attention a new Master Course on Computational Mechanics, which has been awarded the Erasmus Mundus label.

It is an international Master course given jointly in English by the Universidad Politécnica de Cataluña (Barcelona), University of Wales Swansea), Ecole Centrale Nantes and Universität Stuttgart with the collaboration of CIMNE International Centre for Numerical Methods in Engineering, Barcelona). The Erasmus Mundus program:

Prototype for a journal in iMechanica

Hi fellow mechanicians,

Professor Suo and I have devised a model for creating a journal on iMechanica. It is a simple model which doesn’t require installing any additional modules or features.

Alexander A. Spector's picture

Back to the Mechanics vs. Biochemistry in Cellular Mechanotransduction

In his interesting response to our comment posted on 11/28, Ning Wang focused on the transmission of a local force generated at the adhesion site(s). We agree that this is a question important to our understanding of the signaling to the nucleus. The question is not only about the range of the force transmission but also about the magnitude of such force because the nucleus is several times stiffer than the cytoskeleton.

A Model for Superplasticity not Controlled By Grain Boundary Sliding

It is commonly assumed that grain boundary sliding can control plastic deformation in fine grained crystalline solids.  Superplasticity is often considered to be controlled by grain boundary sliding, for example.  I have never accepted that view, though my own opinion is very much at odds with the commonly accepted picture.  When I was asked to write a paper in honor of Professor F.R.N. Nabarro's 90th birthday (Prof.

Mechanical Properties of Thin Films (class notes for a graduate class at Stanford University)

The attached file is a set of class notes developed by W.D. Nix of Stanford University and used in a graduate course on Mechanical Properties of Thin Films. These notes have been used in the graduate course MSE 353 since the late 1980's. That course has been taught every year or so since that time. The notes were last updated in January of 2005. The reader will see a note to the effect that many of the figures and illustrations in the file have been taken from the work of students and colleagues at Stanford without proper attribution.

Hanqing Jiang's picture

Symposium: Multiscale Multiphysics Modeling and Simulation of Nanomaterials and Nanostructures

McMat 2007, June 3-7, 2007, University of Texas at Austin


Call for paper

Symposium: Multiscale Multiphysics Modeling and Simulation of Nanomaterials and Nanostructures


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