Decoupled effects of bone mass, microarchitecture and tissue property on the mechanical deterioration of osteoporotic bones
Based on the theory of composite mechanics, a three-pillar framework “bone mass-microarchitecture-tissue property” instead of “bone mass-bone quality”, is proposed to quantitively characterize the mechanical deterioration of osteoporotic cancellous bones related to the three aspects, and accordingly the individual and integrative influences of bone mass, microarchitecture and tissue property on the mechanical properties of cancellous bones are investigated via the μCT-based finite element method (